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Description [menu]
Asam urat (bahasa Inggris: uric acid, urate) adalah senyawa turunan purina dengan rumus kimia C5H4N4O3 dan rasio plasma antara 3,6 mg/dL (~214µmol/L) dan 8,3 mg/dL (~494µmol/L) (1 mg/dL = 59,48 µmol/L).
Kelebihan (hiperurisemia, hyperuricemia) atau kekurangan (hipourisemia, hypouricemia) kadar asam urat dalam plasma darah ini sering menjadi indikasi adanya penyakit atau gangguan pada tubuh manusia.
Pada manusia, asam urat adalah produk terakhir lintasan katabolisme nukleotida purina, sebab tiadanya enzim urikase yang mengkonversi asam urat menjadi alantoin. Kadar asam urat yang berlebih dapat menimbulkan batu ginjal dan/atau pirai di persendian.
Penyakit asam urat merupakan akibat dari konsumsi zat purin secara berlebihan. Purin diolah tubuh menjadi asam urat, tetapi jika kadar asam urat berlebih, ginjal tidak mampu mengeluarkan sehingga kristal asam urat menumpuk di persendian. Akibatnya sendi terasa nyeri, bengkak dan meradang.
Asam urat adalah penyakit dari sisa metabolisme zat purin yang berasal dari sisa makanan yang kita konsumsi. Purin sendiri adalah zat yang terdapat dalam setiap bahan makanan yang berasal dari tubuh makhluk hidup. Dengan kata lain, dalam tubuh makhluk hidup terdapat zat purin ini, lalu karena kita memakan makhluk hidup tersebut, maka zat purin tersebut berpindah ke dalam tubuh kita. Berbagai sayuran dan buah-buahan juga terdapat purin. Purin juga dihasilkan dari hasil perusakan sel-sel tubuh yang terjadi secara normal atau karena penyakit tertentu. Biasanya asam urat menyerang pada usia lanjut, karena penumpukan bahan purin ini. Uric acid (English: uric acid, urate) is a purine derivative compound with the chemical formula C5H4N4O3 and plasma ratio of between 3.6 mg / dL (~ 214μmol / L) and 8.3 mg / dL (~ 494μmol / L) (1 mg / dL = 59.48 mol / L).
Excess (hyperuricemia, hyperuricemia) or shortage (hipourisemia, hypouricemia) levels of uric acid in blood plasma is often an indication of a disease or disorder in the human body.
In humans, uric acid is a product of purine nucleotide catabolism last track, because the absence of urikase enzyme that converts uric acid into allantoin. Excess levels of uric acid can cause kidney stones and / or gout in the joints.
Gout is the result of excessive consumption of purine substances. Purines into uric acid is processed body, but if excess uric acid levels, so that the kidneys are unable to remove uric acid crystals accumulate in the joints. As a result, joint pain, swollen and inflamed.
Uric acid is a disease of purine metabolic waste substances from the rest of the food we eat. Purine itself is a substance contained in each food derived from living bodies. In other words, the living body there is a purine substances, and because we eat living beings, then such purine substances move into our bodies. A variety of vegetables and fruits also are purines. Purine also resulted from the destruction of body cells which occur normally or because of certain diseases. Usually gout attack in the elderly, because the accumulation of these purine material.
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